Serine - an amino acid independently synthesized by our body!
Mia Hoffmann
2026-03-23
3 min. read
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Amino acids constitute a group of chemical substances composed of two functional groups: amino and carboxyl. These compounds can be divided into two fundamental categories: exogenous amino acids, which are supplied to the body through food or supplements, and endogenous amino acids, which are independently synthesized by our body, including serine. We invite you to familiarize yourself with the following article, where the function of this component in our organism is detailed.
"What is Serine?"
Serine is classified as a native amino acid that stems from glycine. This substance is electrically neutral and also serves as a component of proteins (just like for instance fibroin from silk). In the human body, serine is accumulated in the brain. Seeking natural sources,
The functioning of serine in the body
Sources to supply serine to the body include: – flax seeds, – nuts, – pumpkin and sunflower seeds, – leguminous plants, – fish, – cheese, – sesame, – gelatin (being its richest source). The functioning of serine is, in some sense, regulated by its substrate, which is glycine. D-serine is responsible for controlling the operation of neurons, which are the basic building blocks of our nervous system. It prevents disturbances in concentration and attention. Serine reduces the symptoms of cognitive disorders and diseases with reduced N-methyl-D-aspartate (NMDA) signaling. The latter symptom often occurs in cases of drug addiction or mental disorders such as schizophrenia. The health benefits of serine: – participates in the metabolism of cells, fats, and fatty acids; – supports the immune system in the synthesis of immunoglobulins and antibodies; – participates in the production of proteins, sugars, and other biologically active compounds; – together with glycine, participates in the production of components of nucleic acids; – is a component of the myelin sheath of nerve cells; – regulates analgesic processes (relieving pain).
Dosage and side effects
Eliminates fatty compounds, which is an element of disease prevention in blood vessels; influences muscle tissue development and prevents its loss. Daily doses of serine are calculated based on extensive scientific studies, which typically use doses of 30 mg/kg of body weight. This means that the average dose for a person weighing between 70 and 90 kg is approximately 2,045 to 2,727 mg. It turns out that this is a minimal effective dose aimed at improving the function of cognitive processes. In individuals suffering from schizophrenia, it is assumed that increasing the dose to 60, or even 120 mg/kg of body weight, leads to additional benefits. Serine deficiency is a relatively rare situation and usually occurs as a result of severe illness or malnutrition. Symptoms of too low an amino acid level include a decrease in mood or appearance of depressive states. Overdoses or excessive serine administration do not cause significant side effects.
