The physiological role of manganese in humans: implications of excessive intake and deficiency within the body
Laura Schneider
2026-03-21
3 min. read
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Manganese represents an essential trace element found in the natural environment in diverse chemical configurations—both as organic and inorganic compounds—exhibiting multiple oxidation states. Though present in the human body only in minute trace concentrations, it plays a pivotal role in a wide array of biochemical processes.
Manganese in the body
It affects many enzymes involved in protein and fatty acid synthesis, including those responsible for the production of thyroxine (T4), which is an inactive form of thyroid hormone, and antioxidant enzymes. Its proper level in the body helps the nervous system and brain function. It also affects the pancreas, supports the skin, and helps the bone and connective tissue form properly.
Manganese is scarce
Manganese deficiency is rare due to its widespread presence in food products. In low concentrations in the body, its release with feces is limited. Low levels of manganese can adversely affect the movement and nervous system. There is an increased propensity for bone and joint damage and the risk of osteoporosis.
There's too much manganese
Manganese excess occurs sporadically and is usually not caused by its high intake with diet Exceptions are water rich in manganese and contaminated. Mangana can be neurotoxic.
Manganese poisoning
People who work in the mining, manufacturing, and battery and battery industries are at risk of manganese. Poisoning occurs by injecting. Drug addicts are also at risk for getting ephedrine at home. Excess manganese impairs the functioning of the nervous system and brain, which contributes to Parkinson's disease-like symptoms.
What's manganese in it?
The highest amounts of manganese, up to more than 2 mg per 100 g of product, are found in dark baked goods, whole grain cereals, cassava, nuts, strawberry seeds beans, peas. One cup of tea can provide up to 1.3 mg of this element. Manganese is a trace element in the body. It affects the proper functioning of the nervous system, brain and circulatory system.