Can Creatine Be Harmful? An Analysis of Creatine Supplementation's Effects on Male Fertility
Max Müller
2026-03-23
3 min. read
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In recent years, there has been a significant increase in the popularity of dietary supplements, driven by growing interest in healthy living. Research indicates that nearly 22% of the population regularly consumes various dietary additives. The industry provides a wide array of products designed to accelerate recovery processes, enhance physical performance during workouts, or address nutrient deficiencies. Among the most commonly chosen and well-researched supplements is creatine, which is why we have decided to examine its effects more closely. We invite you to explore our article!
What does creatine do?
Creatine is a naturally occurring compound in the body, specifically in human muscle cells. Intra-systemic synthesis is made possible by three amino acids: arginine, glycine in methionine. This process can occur in the kidneys, pancreas, liver, brain, and in men also in small amounts in the intestine. The total cumulative creatine content in the human body is close to 130 g. There are many positive effects on the market.
Is creatine harmful?
Supplementation with creatine-containing preparations may cause side effects. Among the most commonly reported symptoms are those from the digestive tract, such as diarrhea. However, numerous studies do not document health risks from even long-term supplementation.
Creatine and kidneys
One study published in the Journal of the International Society of Sports Nutrition showed no effect between long-term supplementation with creatine and renal functioning.
Creatine and male fertility
Significant statistical correlations between creatine intake and male fertility improvement have not been demonstrated.
Creatine before or after training
The best time to take creatine is during the training period. This is confirmed by studies conducted by Antonio and Ciccone, which showed a greater increase in muscle mass in people taking supplementation during training period than before the planned training unit.