Adiponectin and ghrelin – pivotal hormones governing satiety and appetite regulation
Tomasz Jankowski
2026-03-21
3 min. read
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Every living organism is endowed with an intrinsic temporal mechanism that meticulously partitions activity between daytime and nocturnal phases. Even when daily schedules deviate from this innate rhythm, disregarding its signals impairs our capacity for optimal performance. The contemporary pace of life, burdened by an excess of obligations, frequently erodes these boundaries—rather than resting during nighttime hours, we remain in a state of alertness. Curiously, despite potential disruptions to our biological clock, body weight remains at a steady, and at times even ideal, level, suggesting the presence of sophisticated compensatory mechanisms.
Leptin and ghrelin
While ghrelin and leptin are the two opposite hormones responsible for satiety and hunger, it's true that our weight is determined to some extent by different types of diet and exercise, but they are the ones that determine the effectiveness of the weight loss process.
Leptin and weight loss
Leptin is a hormone that sends information to our brain that we're fed, so we don't want to have another snack. So leptin is the satiety hormone, and the less leptin, the weaker the signal gets to the brain and the more we have to eat in order to get full.
Grelin is the hunger hormone
It's also good news for people who exercise regularly, but it's bad news that we get hungry and we want to have another snack. So the more grill we have, the more we can eat. So it is good to know when its levels go up and when they go down. It only goes down after a meal or during physical activity, and that's good news to people who work out regularly. But there is also bad news.