Search
logo
Search
The article is in preview mode

What is the effect of food on medicines?

Homepage Articles What is the effect of food on medicines?

What is the effect of food on medicines?

The inclusion of these effects in pharmacotherapy is important for its safety and efficacy.It can apply to medicines, dietary supplements, but also to food products and the nutrients supplied with them.An interaction is a phenomenon in which two or more substances interact in such a way that their effects on the body are modified.

Table of Contents

1. The effect of food on medicine

Most of the ingredients in the diet of the average person affect the compounds in pharmaceutical products at the time of absorption (60% of all interactions). These interactions can lead to a lack or impairment of the medicinal product, the occurrence of side effects and side effects, an increased risk of toxicity or the intensification of the drug.

2. Combining medication with food

It is important to clarify exactly what the most commonly given recommendations mean. Fasting on an empty stomach, the last meal eaten the night before. Before eating at least 3060 minutes before the start of a meal. During meals a few minutes after the beginning of the meal, but before the end of it. After eating at least 30??60 minutes after eating. Regardless of the juice any time. One of the factors disrupting this process is the presence of dietary fiber.

3. Food ingredients and absorption of medicines

The direction of this action depends on the physicochemical properties of the drug, including its solubility and its ability to form complexes with other ingredients. For example, magnesium may reduce the absorption of antibacterial drugs, reduce the strength of the action of nasal glycosides, or increase the effect of levodopa used in the treatment of Parkinson' s disease. The main nutrients that have a specific effect on pharmaceutical drugs include fat. This leads to a decrease in the concentration of the anti-bacterium drug and its metabolites. It is also possible to reduce the effects of absorption by pharmaceuticals, if nitroglycosides may increase the effects on these compounds, and, in some cases, may also have an effect on the metabolism of certain medicines, such as beta- and anti-inflammatory drugs.

4. The effect of dietary fiber

One of the most commonly prescribed antidepressant medicines is leukaemia, which results in a reduction in the time it takes to empty the stomach and an acceleration in the blood flow of the digestive tract (e.g. posthumously administered blood glucose may also occur when blood sugar levels are low, and cholesterol levels may also increase).

5. What's the medicine to drink?

The micronutrients present in highly mineralized water can make it difficult for some medicines to be absorbed. In order to avoid drug interaction with the drink, it is best to drink it with non-carbonated water.

6. Drug interactions with fluids

This process instead of the intestines will take place in the stomach, which will affect not only the action of the medicine but also the irritation of the mucous membrane. This element weakens the effects of some antibiotics (including tetracycline) and levothyroxine (used in the treatment of thyroid diseases) because it creates complexes that hinder absorption. These should be taken at least one hour before a calcium-rich meal or 2 hours after it is taken. After the first milk changes the pH of your stomach so that some substances can be dissolved earlier than usual.

Category:
Source

Bojarowicz H., Dźwigulska P., Suplementy diety. Część III. Interakcje suplementów diety z lekami, „Hygeia Public Health” 2012, 47(4), 442–447.
Cuthill J.M. et al., Death associated with tranylcypromine and cheese, „The Lancet” 1964, 283(7342), 1076–1077.
Fernandez N. et al., Effects of dietary factors on levodopa pharmacokinetics, „Expert Opinion on Drug Metabolism & Toxicology” 2010, 6(5), 633–642.
Flockhart D.A., Dietary Restrictions and Drug Interactions With Monoamine Oxidase Inhibitors: An Update, „The Journal of Clinical Psychiatry” 2012, 73(suppl 1), 17–24.
Hung S. et al., Dietary fiber improves lipid homeostasis and modulates adipocytokines in hamsters, „Journal of Diabetes” 2009, 1(3), 194–206.
Kłoda K. et al., Wpływ spożywanych owoców cytrusowych oraz egzotycznych i ich soku na metabolizm leków, „Farmacja Współczesna” 2013, 6, 191–195.
Korzeniowska K., Jabłecka A., Interakcje leków z pożywieniem, „Farmacja współczesna” 2008, 1, 24–30.
Sobotta Ł., Suliburska J., Mielcarek J., Interakcje lek – żywność, „Bromatologia i Chemia Toksykologiczna” 2011, 1, 95–103.
Staniszewska A., Wpływ pożywienia na farmakoterapię, Psychodietetyka, pod red. Brytek-Matery A., Warszawa 2021, 291–307.
Styszyński A. et al., Znaczenie interakcji leków i pożywienia w racjonalnej farmakoterapii, „Geriatria” 2016, 10, 184–188.
Van den Eynde V., Gillman P.K., The larger than linear effect of high-dose tyramine on systolic blood pressure – the MAOI diet modified, „International Journal of Psychiatry in Clinical Practice” 2020, 24(3), 328.
Zieleń-Zynek I. et al., Interakcje wybranych leków kardiologicznych ze składnikami diety, „Folia Cardiologica” 2019, 14(1), 46–51.