Search
Language
The role of leptin in weight regulation how to reverse leptin resistance
Table of Contents
1. The functions of leptin in the human body
A high level of leptin in the blood informs the body that it has adequate energy reserves, which results in a decrease in appetite and a reduction in food intake. Pereira et al. (2021). Obradovic et al., 2021). Its most important task is to regulate appetites and feelings of satiety by affecting the subcutaneous portion of the brain that controls hunger. By stimulating the synaptic system, this hormone affects many metabolic processes, including lipolysis and weight maintenance, which allows the body to maintain energy balance (S. In addition to affecting hunger, the hormone plays a key role in many physical processes.2. Leptin resistance
Despite the fact that leptin levels are elevated, the brain does not receive its signals about adequate energy reserves, which leads to impaired appetite and metabolism regulation mechanisms. This phenomenon is often associated with obesity because in people with excess body weight, the leptin produced by fat cells can accumulate in large quantities. Leptin resistance is a condition in which the body loses the ability to respond properly to leptin, even though its levels in the blood are high.3. Causes of leptin resistance
Inflammatory conditions, especially within the fat tissue, lead to the production of substances that can interfere with the proper action of leptin on its receptors in the brain. Liu et al. 2018).4. Symptoms of leptin resistance
Symptoms of leptin tolerance can often be confused with symptoms of other health problems, which makes it difficult to diagnose early. Liu et al. 2018). The most common symptoms include: increased appetite and uncontrolled hunger, difficulty maintaining a normal body weight even decreased calorie intake, and increased physical activity. However, people with leptin resistance may have difficulty reducing weight.5. Diagnosis of tissue resistance to leptin
Measurement of blood leptin levels in combination with glucose and insulin levels analysis may indicate a problem with sensitivity to this hormone. A thorough analysis of test results and symptoms allows an accurate diagnosis of leptin resistance (J. Leptin tolerance diagnosis is based on an assessment of clinical symptoms and laboratory results. An important component of the diagnosis is also associated factors such as chronic inflammation or excessive deposition of adipose tissue within the abdomen. Liu et al. 2018).6. The effects of leptin resistance
As a result, leptin tolerance is one of the main factors contributing to obesity and other metabolic problems such as insulin resistance, type 2 diabetes, metabolic syndrome, or cardiovascular disease (T. Leptin resistance is a consequence of increased hunger, which leads to excessive food intake and, in the long run, an increase in fat tissue levels in the body. Vilariño-García et al. 2024).7. How to reverse leptin resistance
Reversing leptin resistance requires a comprehensive approach that includes changes in diet, lifestyle and management of stress and inflammation.8. The Commission shall adopt delegated acts in accordance with the opinion of the Standing Committee on Plants, Animals, Food and Rural Affairs and the Committee on the Environment, Public Health and Consumer Protection
It should therefore be based on high-fiber foods (vegetables, fruits, whole grains), unsaturated fatty acids (especially omega-3s found in, for example, fatty seafood) and protein, the proper amount of which in the diet helps to control appetite and maintain satiety for longer. It is also important that all meals are well balanced and contain all sources of macronutrients so as to help avoid stabilizing glucose levels (K. The diet plays a key role in the fight against leprosy.9. Regular physical activity
In turn, strength training helps build muscle mass, which increases energy expenditure and improves metabolism (R.A. Exercise has a direct effect on improving leptin sensitivity. Jadhav et al. 2021). Regular physical activity, especially aerobic training (e.g. fast walking, running, swimming), improves the functioning of the hormonal system and promotes the reduction of inflammation.10. Stress management and improved sleep quality
Bouillon-Minois et al. 2021). Liu et al., 2022). Stress and lack of sleep have a negative impact on leptin sensitivity. Prolonged sleep deprivation also changes the way the body reacts to leptin (S. Important to ensure adequate amount and quality of sleep (78 hours per day) and to introduce stress reduction techniques such as meditation, yoga, or deep breathing.11. Weight control
However, a key element is the gradual loss of kilograms through the introduction of a healthy, balanced diet and regular physical activity. Izquierdo et al. 2019). However, studies indicate that even a small reduction in body weight (by a few kilograms) can significantly improve the body's sensitivity to leptin.12. In the case of the 'extra_id_0>', the 'extras' shall be replaced by 'extraterrestrials'
Albracht-Schulte et al. 2018), vitamins D (I. Musazadeh et al., 2024) and probiotics that help maintain gut health and may affect hormonal balance (Y. However, before deciding whether to use them, it is important to consult a doctor who will help you get the right doses and ensure their safety. Early diagnosis of the problem is key, so regular consultation with a doctor and monitoring of leptin, insulin and other metabolic markers levels is an important component of effective treatment and adaptation of appropriate therapeutic strategies.
