Search
logo
Search
The article is in preview mode

Testosterone treatment indications, effects, and health risks

Homepage Articles Testosterone treatment indications, effects, and health risks

Testosterone treatment indications, effects, and health risks

Although low testosterone levels are a problem for many men, deficiencies of this important hormone are unfortunately becoming increasingly common among young and physically active people, and if diet, supplementation, and lifestyle changes do not improve, it is worth considering testosterone replacement therapy.

Table of Contents

1. How testosterone is made and how it functions

Testosterone is also directly related to the building and functioning of the male sex organs. In addition, it must not be forgotten that testosterone has a large effect on sexual performance (libido). However, this hormone has a major effect on the process of muscle tissue and contributes to the stimulation of the growth of muscle mass. It also plays an important role in women's physical fitness. Its function in testosterone is to regulate the body's metabolism of hormones and hormones, as well as in the development of the prostate glands. It is the most important factor in the production of testosterone, and it is also important for the growth and development of hormone hormones in the body.

2. Testosterone replacement therapy indications and preparations used

The main indication for testosterone therapy is to lower its level due to primary or secondary hypogonadism. In addition, TRT is a frequent way to counteract various hormonal disorders that result from regular and intensive training. In TRT, laboratory diagnosis plays a key role because it is on the basis of which patients are classified for starting hormone replacement therapy (HRT). In the case of testosterone, its blood values are largely consistent with the individual organization of testosterone therapy for patients. Testosterone testosterone therapy with testosterone can be administered in different forms from the initial administration of testosterone to the primary hormone therapy, and can be delivered in a variety of forms, such as oral therapy, oral therapy and oral and oral therapy.

3. The role of diagnosis before treatment

While there is no direct risk of TRT, early diagnosis in men over the age of 40 minimizes the chance of concealed cancer. Testosterone injections are associated with additional increases in these parameters, which can result in a health hazard and an increased risk of thromboembolism. There is no immediate risk of TTR, but early diagnosis reduces the risk of hidden cancer. In addition, it is believed that external testosterone administration may contribute to the progression of cancer levels, which is associated with increased testosterone levels in the prostate (D.A. thromboemoglobin therapy) with PSA (TTR) hormone therapy.

4. Assessment of the effectiveness of testosterone therapy

In addition, it is recommended that testosterone tests be performed every year. However, if there is no improvement after the target testosterone level is reached, then continuation of TRT is unfounded and treatment should be discontinued. Beneficial changes in lean muscle mass, libido and sexual performance may occur between the 3rd and 6th months of treatment.

Source

Barbonetti A. et al., Testosterone replacement therapy, „Andrology” 2020, 8(6), 1551–1556.
Barbosa L.P. et al., Relationship between inflammatory biomarkers and testosterone levels in male master athletes and non-athletes, „Experimental Gerontology” 2021, 151, 111407.
Baasil N. et al., The benefits and risks of testosterone replacement therapy: a review, „Therapeutics and Clinical Risk Management” 2009, 427–448.
Clark R.V. et al., Large divergence in testosterone concentrations between men and women: frame of regerence for elite athletes in sex-specific competition in sports, a narrative review, „Clinical Endocrinology” 2019, 90(1), 15–22.
Gagilano-Juca T., Basaria S., Testosterone replacement therapy and cardiovascular risk, „Nature Reviews Cardiology” 2019, 16(9), 555–574.
Gruenewald D.A., Matsumoto A.M., Testosterone supplementation therapy for older man: potential benefits and risks. „Journal of the American Geriatrics Society” 2003, 51(1), 101–115.
Park H.J. et al., Evolution of guidelines for testosterone replacement therapy, „Journal of Clinical Medicine” 2019, 8(3), 410.
Shokes J.J. et al., Pharmacology of testosterone replacement therapy preparations, „Translational Andrology and Urulogy” 2016, 5(6), 834–843.
Storer T.W. et al., Effects of testosterone supplementation for 3 years on muscle performance and physical function in older men, „The Journal of Clinical Endocrinology & Metabolism” 2017, 102(2), 583–593.