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Postbiotics are what they are and how they work

Homepage Articles Postbiotics are what they are and how they work

Postbiotics are what they are and how they work

For this reason, many researchers are working on ways to influence the composition of the microbiota and restore it to its normal state. Recently, however, a new group of postbiotics is gaining popularity. In recent years, there has been a growing awareness of the impact of the microbes (the bacteria that inhabit the body) on human functioning. Presently, prebiotics, probiotics and synbiotics are primarily used for this purpose. It is therefore worthwhile to look at what they are and what their mechanism of action is, as well as how they differ from other preparations. Disorders in their composition can contribute to the development of, among others, allergies and autoimmune diseases.

Table of Contents

1. Additional information to be included in this section

Because of their similar names and uses, probiotics, prebiotics and synbiotics can be easily confused with each other, but what distinguishes them is their composition. Probiotics are living bacteria that affect the functioning of the body, Prebiotic are food ingredients that are not digested by the human body; they are food for probiotic bacteria; Postbiotics is non-nutritive bacteria and the products of bacterial metabolism; ?? Synbiotic is a combination of probiotical bacteria and prebiotic products; they do not include the elements of probiotica.

2. Selected postbiotics and how they work

The group of postbiotics can include a variety of substances, including proteins, carbohydrates, vitamins, organic acids, short-chain fatty acids and amino acids as well as fragments or whole bacterial organisms.

3. It's not live bacteria

Some inactive strains of Lactobacillus (often used in probiotics) also act as an anti-inflammatory (inhibits the secretion of proinflammatoires and stimulates the production of these anti- inflammatory substances) and an antioxidant (by eliminating free relatives) and also increase the synthesis of serotonin, known as the happiness hormone, and decrease the action of hunger hormones. However, research suggests that even antibiotic methods are beneficial to the body, and the most common cause of bacterial death is the death of bacteria.

4. They're cellless supernatants

In one study, Lactobacillus strain supernatants were found to exhibit anti-inflammatory and anti-oxidant activity in gut cells. De Marco et al. 2018). In a study published in 2017, the authors noted that supernates of different strains of probiotic bacteria were effective in fighting the pathogenic diseases Escherichia coli. Khodaii, S. Natanzi 2017). De Marco and others. In addition, different species of bacteria affect the expression of different inflammatory factors (e.g. Interleukin 1, 6 and 8 and TNF-α) and antiinflammable factors (interleukin 10), which prevents the ability of a patient to develop a barrier to infection.

5. The following is the list of keywords:

They have antibacterial and anti-inflammatory effects, as well as inhibiting cholesterol absorption, which contributes to the prevention of heart disease (J. They are carbohydrates produced and excreted by bacteria during their growth; they include cellulose, dextrane or xanthan.

6. Short-chain fatty acids

Short-chain fatty acids may also contribute to improved insulin sensitivity, reduce the risk of infection, and inhibit cholesterol synthesis. This effect has been associated with a reportedly higher concentration of fatty acid, which, by acting on the receptors in the cells, increases their susceptibility to insulin and decreases the deposition of adipose tissue in the gut (R. They are a product of the conversion of material produced during bacterial fermentation.

7. The advantages and disadvantages of postbiotics

Nevertheless, at the end of the shelf-life, the micro-organism content of the preparation is often much lower than that declared by the manufacturer. This means that the preparations can have a longer shelf life. Moreover, the post-biotic components could potentially be used as a functional food item, i.e. products in which substances have a beneficial effect on health either naturally or as an additive. The lack of human studies means that their efficacy is currently unknown, necessary to produce a single effect, the long-term effects of their action, as well as the requirements for the conditions of the organisms producing and storing them. Probiotics must also be produced, transported and used under the appropriate conditions, in order to ensure that their resistance is not compromised by the use of antibiotics, which means that they do not have a significant impact on the lives of humans.

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Aoki R. et al., A proliferative probiotic Bifidobacterium strain in the gut ameliorates progression of metabolic disorders via microbiota modulation and acetate elevation, „Scientific Reports” 2017, 7, epub.
De Marco S. et al., Probiotic Cell-Free Supernatants Exhibited Anti-Inflammatory and Antioxidant Activity on Human Gut Epithelial Cells and Macrophages Stimulated with LPS, „Evidence-based Complementary and Alternative Medicine” 2018, 2018, epub.
Khodaii Z., Ghaderian S., Natanzi M., Probiotic Bacteria and their Supernatants Protect Enterocyte Cell Lines from Enteroinvasive Escherichia coli (EIEC) Invasion, „International Journal of Molecular and Cellular Medicine” 2017, 6(3), 183–189.
Nataraj B.H. et al., Postbiotics-parabiotics: the new horizons in microbial biotherapy and functional foods, „Microbial Cell Factories” 2020, 19(1), epub.
Salminen S. et al., The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics, „Nature Reviews. Gastroenterology & Hepatology” 2021, 18(9), 649–667.
Singh T.P. et al., Antagonistic Activity of Lactobacillus reuteri Strains on the Adhesion Characteristics of Selected Pathogens, „Frontiers in Microbiology” 2017, 8, epub.
Żółkiewicz J. et al., Postbiotics – A Step Beyond Pre- and Probiotics, „Nutrients” 2020, 12(8), epub.