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Insulin resistance symptoms, causes and diagnosis
Table of Contents
1. The history and role of Poland:
It stimulates the uptake of glucose from the blood and the synthesis of fatty acids and glycogen in the liver. Most receptors for insulin are found in the fat cells, liver, and transverse tissue. Glucose is transported to the cell by glucose transporters GLUT, the amount of which is different from that of insulin in the cell. Insulin is secreted into the bloodstream by increasing the concentration of glycemic, fatty, and amino acids in the blood.2. What is insulin resistance?
Interestingly, insulin resistance has its evolutionary explanation because it helped our ancestors survive in difficult conditions by saving glucose resources. Studies of tribal members who lead lifestyles similar to our forefathers, hunter-gatherers, have shown that they are highly insulin resistant.3. Insulin resistance is a patho-mechanism
The body tries to compensate for this with hyperinsulinemia, but nevertheless blood glucose levels remain high because the cells are unable to absorb glucose from the outside. Under physiological conditions, insulin has anti-lipolic properties and prevents excess free fatty acids from being taken after a meal. This is extremely dangerous because it can lead to so-called lipotoxicity, or fat accumulation in the muscles, the liver and also the beta cells of the pancreas. Consequently, insulin acid is another factor that increases the level of glucose in the blood.4. Insulin resistance Symptoms may occur
impaired glucose tolerance, increased lipid parameters (total cholesterol, triglycerides), elevated uric acid levels in the blood,5. Insulin resistance is the cause
Cortisol is a hormone synthesized by the adrenal cortex and supports the body in stressful situations. cortisol affects the carbohydrate economy in many ways by: disrupting glucose uptake in tissues, stimulating the release of glucose from glycogen in the liver, ?? stimulates gluconeogenesis (the process of converting non-sugar compounds such as amino acids or dairy products into glucose), inhibiting the secretion of insulin.6. Insulin resistance and disease
In addition, in liver cells, the inhibitory effects of insulin on gluconeogenesis and abdominal obesity are eliminated, which in turn increases hyperglycaemia, thereby creating a cause-and-effect cycle of error. Insulin resistance is the leading cause of type 2 diabetes and occurs many years before it develops. Fat deposition can lead to internal organ obesity and stomach obesity, which later is also a source of free fatty acids and triggered by a false cycle of dependence. For example, there may be an increase in the metabolic rate of polycystic ovarian hormones (PCOS) due to hypoglycemia and insulin resistance due to pregnancy, which may not lead to a significant increase in metabolic rates of insulin, which can cause large increases in blood glucose levels, in patients with diabetes mellitus, or in patients who are diagnosed with PCOS.7. Insulin resistance is the diagnosis
Based on these two parameters, the following indicators can be calculated: HOMA (HOMA-IR, homeostatic model assessment) is calculated according to the formula: fasting insulin concentration (mU/ml) × fasting glucose concentration (mmol/l) / 22.5 above 1 indicates insulin resistance, QUICKI (Homostatic insulin sensitivity and quantity check index) is based on a formula: 1/log insulin concentration per minute (μU/ ml) + log glucose per minute concentration per ml (mmul/ l) below 0.34 indicates glucose tolerance.8. Insulin resistance treatment
If a person with insulin resistance is obese, he or she should start treatment with weight loss. Lactobacillus rhamnosus GG. Insulin resistance can be treated pharmacologically with insulin-sensitive medicines such as metformin, but it can reduce vitamin B12 levels, so it should be controlled in people taking this medicine.9. The insulin-resistant diet
The most common are type II diabetes, obesity, hypertension, asthma, some cancers, bowel infections, allergies. This is often the first step taken by specialists. The diet is an excellent foundation for physician-led pharmacological treatment. Depending on the disease, the need for individual ingredients may also increase or decrease. We take into account disease, chronic hygiene treatment, medical advice, some cancer research, which allows us to better adapt our diets to the needs of our bodies. We may be able to balance these nutrient sources in the context of an organism's daily diet, and we may not need to adjust our dietary intake to meet all the needs and needs of the organism, but we can always take into consideration the long-term health and nutritional needs of patients, and if possible, we can provide adequate food and energy in a timely manner, in order to reduce the risk of diseases, such as diabetes and other diseases.
